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nbr1 protein  (Federation of European Neuroscience Societies)

 
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    Federation of European Neuroscience Societies nbr1 protein
    Nbr1 Protein, supplied by Federation of European Neuroscience Societies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/nbr1+protein/nbr1+protein/pm33774929-276-15-7
    Average 90 stars, based on 1 article reviews
    nbr1 protein - by Bioz Stars, 2026-10
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    other:

    Article Title: Creativity comes from interactions: modules of protein interactions in plants.
    Article Snippet: Arabidopsis 15The FEBS Journal (2021) a 2021 Federation of European Biochemical Societies NBR1 has an N-terminal PB1 domain as well as two ubiquitin-associated (UBA) domains at the C terminus, which bind ubiquitin through a conserved hydrophobic patch [144].

    Article Title: Autophagy and tumorigenesis.
    Article Snippet: Although p62 and NBR1 act similarly, having different cargo 3The FEBS Journal (2021) a 2021 Federation of European Biochemical Societies receptor proteins provides a high degree of selectivity in the autophagic process.



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    ULK2 is essential for skeletal muscle homeostasis. Our studies reveal that the Ulk2 gene presents a skeletal muscle–enriched pattern of expression in mice and that its deficiency in skeletal muscle, despite not impairing autophagy flux and proteolytic activities of the lysosome and proteasome, leads to robust accumulation of insoluble ubiquitinated protein aggregates associated with the adaptors p62 and NBR1. These findings suggest a key role for ULK2 in modulating the recognition and sequestration of ubiquitinated protein aggregates for degradation by autophagy (and potentially by the proteasome). The ensuing inability of ULK2-deficient muscle fibers to clear proteotoxic aggregates leads to atrophy, impaired force production, myofiber degeneration, and a generally unhealthy morphology of the muscle. Of note, these cellular events and functional outcomes are not observed in ULK1-deficient muscle. Autophagy is depicted with a phagophore and an autophagosome (white) and lysosome (blue).

    Journal: The FASEB Journal

    Article Title: ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscle

    doi: 10.1096/fj.201900766R

    Figure Lengend Snippet: ULK2 is essential for skeletal muscle homeostasis. Our studies reveal that the Ulk2 gene presents a skeletal muscle–enriched pattern of expression in mice and that its deficiency in skeletal muscle, despite not impairing autophagy flux and proteolytic activities of the lysosome and proteasome, leads to robust accumulation of insoluble ubiquitinated protein aggregates associated with the adaptors p62 and NBR1. These findings suggest a key role for ULK2 in modulating the recognition and sequestration of ubiquitinated protein aggregates for degradation by autophagy (and potentially by the proteasome). The ensuing inability of ULK2-deficient muscle fibers to clear proteotoxic aggregates leads to atrophy, impaired force production, myofiber degeneration, and a generally unhealthy morphology of the muscle. Of note, these cellular events and functional outcomes are not observed in ULK1-deficient muscle. Autophagy is depicted with a phagophore and an autophagosome (white) and lysosome (blue).

    Article Snippet: The following antibodies and respective dilutions were used for immunoblots: sequestosome 1 (SQSTM1) (p62) (P0067, 1:1000), ULK1 (A7481, 1:1000), FLAG (F1804, 1:1000) from MilliporeSigma, ULK2 (HPA009027, 1:500) from MilliporeSigma, next to breast cancer type 1 susceptibility protein gene 1 protein (NBR1) (sc-130380, 1:1000) from Santa Cruz Biotechnology (Dallas, TX, USA), LC3A/B (4108, 1:1000), ubiquitin (3936, 1:1000), cathepsin B (CTSB) (31718, 1:1000), lysosomal associated membrane protein 1 (LAMP1) (9091, 1:1000), autophagy related protein (Atg)13 (13273, 1:1000), Atg14 (5504, 1:1000), phosphorylated (p-)Atg14 (S29) (13155, 1:1000) from Cell Signaling Technology (Danvers, MA, USA), ULK2 (NBP1-33136, 1:500) from Novus Biologicals, p-p62 (S403) (MABC186-I, 1:1000) from MilliporeSigma, p-Atg13 (S318) (600-401-C49S, 1:1000) from Rockland (Limerick, PA, USA), and 20S (ab22673, 1:1000) from Abcam (Cambridge, United Kingdom).

    Techniques: Expressing, Functional Assay